Ph.D. in Department of Ecological Science (March 2015 – February 2019)

Kyungbook National University, Republic of Korea

 

M.S in Department of Ecological Science (March 2013 – February 2015)

Kyungbook National University, Republic of Korea

 

B.S in Department of Applied Biology (March 2007 – February 2013)

Kyungbook National University, Republic of Korea

Postdoctoral Researcher in Department of Neurology and RNA Therapeutics Institute (March 2019 – July 2026)

University of Massachusetts Medical School

 

 

1.  2026 Gordon Research Conference, Frontotemporal Dementia and Related Rare Dementias (2026.02.16)
Title: The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD

2.  2025 NEBS Annual Conference (2025.05.17)
Title: SIRT1-Mediated p53 Suppression Alleviates DNA Damage and Rescues Neurodegeneration in ALS/FTD

3.  2023 NEBS Annual Conference (2023.05.13)
Title: Myosin IIB links ESCRT III to parkin-mediated mitophagosome to maintain neuronal homeostasis

4.  2021 KASBP Fall eSymposium (2021.11.13)
Title: Myosin IIB links ESCRT III to parkin-mediated mitophagosome to maintain neuronal homeostasis

5.  Autophagy Symposium (KSBMB International Conference)
Title: Elucidation of Autophagosome-Targeting Mechanism of the Legionella Anti-autophagy Effector RavZ and Its Application

6.  Joint Japan-Korea-China Young Investigator Conference (A3)
Title: Development of LC3- or GABARAP- specific autophagosome sensors

 

 

1.  2026 Gordon Research Conference (2026.02.16)
Title: The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD

2.  2025 RNA Therapeutics Symposium (2025.06.27)
Title: Downregulation of SIRT1 by Mutant CHMP2B Contributes to DNA Damage and Neurodegeneration in Frontotemporal Dementia

3.  2023 NEBS Annual Conference (2023.05.13)
Title: Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis

4.  Annual Packard Center ALS Research Symposium, Baltimore, U.S.A (2023.02.27)
Title: Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis

5.  Keystone Symposia 2022, Colorado, U.S.A (2022.05.07)
Z1: Neuro-Immune Interactions in the Central Nervous System, Z2: Neurodegeneration
Title: Non-Muscle Myosin IIB Links ESCRT-III to Parkin-Mediated Mitophagy to Maintain Neuronal Homeostasis.

6.  Society for Neuroscience 2018, San Diego, U.S.A (2018.11.03~07)
Title: Development of efficient autophagosome sensors by detecting endogenous LC3 using modified Legionella RavZ.

7.  Autophagy Symposium(KSBMB International Conference), Byeonsan, Korea (2018.08.30~31)
Title: Development of chemically inducible GFP fused protein probes detecting phosphatidylinositol-3-phosphate (PI3P) in the living cells.
Title: Elucidation of Autophagosome-Targeting Mechanism of the Legionella Anti-autophagy Effector RavZ and Development of Novel Autophagosome Sensors Detecting Specific mATG8 by the Modification of RavZ.
Title: A novel assay to characterize the binding property of LC3/GABARAP family with its target LIRs in live cells.

8.  A3 conference in Niigata 2018, Japan (2018.10.29~31)
Title: A novel assay to characterize the binding property of LC3/GABARAP family with its target LIRs in live cells.
Title: Improvement of LC3/GABARAP sensors to monitor LC3/GABARAP specific autophagosome.

9.  Society for Neuroscience 2017, Washington, D.C., U.S.A (2017.11.11~15)
Title: Development of LC3-GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy and its application in neurological disorders.

10.  Autophagy Symposium 2017 (KSBMB International Conference), Yangyang, Korea (2017.08.24~25)
Title: Fluorescence-based novel assay to analyze binding property of LIR motif-containing proteins with each LC3/GABARAP protein.
Title: Development and improvement of LC3/GABARAP sensors to monitor selective autophagy.

11.  The 8th International Symposium on Autophagy 2017, Nara, Japan (2017.05.29~2017.06.01)
Title: Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.

12.  Society for Neuroscience 2016, San Diego, U.S. A (2016.11.12~16)
Title: Dissection of molecular mechanism of Aplysia Sec7 protein-induced neurite outgrowth.

13.  Autophagy Symposium 2016 (KSBMB International Conference), Yangyang, Korea (2016.08.25~26)
Title: Development of a New Autophagosome Sensor with an LC3-Interacting Region (LIR) Motif and a Hydrophobic Domain.

14.  KSBMB International Conference 2016, Seoul, Korea (2016.05.18~20)
Title: Dual roles of the N-terminal coiled-coil domain of an Aplysia sec7 protein: homodimer formation and nuclear export.

15.  The Korean Society for Brain and Neural Science 2015, Seoul, Korea (2015.09.11~12)
Title: PI4P as a lipid marker for presynaptic terminal targeting in Aplysia sensory neurons.

16.  Autophagy Symposium 2015 (KSBMB International Conference), Yangyang, Korea (2015.08.27~28)
Title: Development of a new autophagosome sensor with a LC3-interacting region motif and the hydrophobic domain.

17.  The Korean Society for Brain and Neural Science 2015, Korea (2015.09.11~12)
Title: Molecular mechanism of Aplysia Sec7-induced neuritogenesis in neurons.

18.  KSBMB International Conference 2015, Seoul, Korea (2015.05.12~14)
Title: Additional Roles of Short C-terminal Length of C4orf52 for Selective Mitochondria Outer Membrane Targeting.
Title: D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane.

19.  Mitochondria Symposium (International Conference KSMCB) (2015.06.11)
Title: Additional Roles of Short C-terminal Length of C4orf52 for Selective Mitochondria Outer Membrane Targeting.
Title: D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane.

20.  KSBMB International Conference 2014, Seoul, Korea (2014.05.14~16)
Title: Intracellular membrane association of the Aplysia cAMP phosphodiesterase long- and short-forms via different targeting mechanisms.

21.  The Korean Society for Brain and Neural Science 2014, Korea (2014.11.06~08)
Title: Intracellular membrane association of the Aplysia cAMP phosphodiesterase long- and short-forms via different targeting mechanisms.

22.  Society for Neuroscience 2014, Washington, D.C., U.S.A (2014.11.15~19)
Title: Intracellular membrane association of the Aplysia cAMP phosphodiesterase long- and short-forms via different targeting mechanisms.

23.  KSBMB International Conference 2013, Seoul, Korea (2013.05.14~16)
Title: A targeting of ApPDE4 short-form to plasma membrane is determined by an electrostatic interaction.

24.  International Conference KSMCB 2012, Seoul, Korea (2012.05.30~2012.06.01)
Title: Characterization of the lipid binding property of newly cloned ApSec7 using newly developed lipid binding approaches.

 

 

 

1.  Jun YW, Hass EP, Lee S, Fazzio TG, Gao F-B, “Mislocalization of FTD3-Associated Mutant CHMP2B to the Nucleus of Human Neurons Due to Loss of a Nuclear Export Signal”, Acta Neuropathologica Communications, 2026 Jan 20;14(1):45. (First author)

2.  Jun YW*, Lee S*, Almeida S, Freude KK, Ichida JK, Gao F-B, “The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD”, Nature Communications, 2025 Dec 20;17(1):1007. (*Co-first author)

3.  Fyrberg E, Learnard H, Lee S, Jun YW*, Gao F-B*. "New mouse lines that drive tetracycline-controlled gene expression in a small subset of spinal cord dorsal horn neurons" eNeuro, 2025 Apr 8;12(4):0441-24.2025 (*Co-corresponding author)

4.  Jun YW, Lee S, Ban BK, Lee JA, Gao F-B. "Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis" Autophagy, 2023 Jul;19(7):2045-2061. (First author)

5.  Lee S, Jun YW, Gabriel R Linares, Brandon Butler, Yeliz Yuva-Adyemir, Jill Moore, Gopinath Krishnan, Bryan Ruiz-Juarez, Manuel Santana, Marine Pons, Neal Silverman, Zhiping Weng, Justin K Ichida, Gao F-B. "Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD" Neuron, 2023 May 3;111(9):1381-1390.e6. (Second author)

6.  Park SW, Jeon P, Yamasaki A, Lee HE, Choi H, Mun JY, Jun YW, Park JH, Lee SH, Lee SK, Lee YK, Song HK, Lazarou M, Cho DH, Komatsu M, Noda NN, Jang DJ, Lee JA. "Development of new tools to study membrane-anchored mammalian Atg8 proteins" Autophagy, 2023 May;19(5):1424-1443. (Co-author)

7.  Park JH, Lee SH, Park SW, Jun YW, Kim KH, Jeon P, Kim M, Lee JA, Jang DJ. "Deciphering the role of a membrane-targeting domain in assisting endosomal and autophagic membrane localization of a RavZ protein catalytic domain." BMB Reports, 2021 Feb 28;54(2):118-123. (Co-author)

8.  Park SW*, Jun YW*, Jeon P, Lee YK, Park JH, Lee SH, Lee JA, Jang DJ. "LIR motifs and the membrane-targeting domain are complementary in the function of RavZ." BMB Reports, 2019 Dec 31;52(12):700-705. (*Co-first author)

9.  Park SW, Jeon P, Jun YW, Park JH, Lee SH, Lee S, Lee JA, Jang DJ. "Monitoring LC3- or GABARAP-positive autophagic membranes using modified RavZ-based probes." Scientific Reports, 2019 Nov 12;9(1):16593. (Co-author)

10.  Park SW*, Jun YW*, Choi HE, Lee JA, Jang DJ. "Deciphering the molecular mechanisms underlying the plasma membrane targeting of PRMT8." BMB Reports, 2019 Oct 31;52(10):601-606. (*Co-first author)

11.  Jun YW, Lee JA, Jang DJ. "Novel GFP-fused protein probes for detecting phosphatidylinositol-4-phosphate in the plasma membrane." Animal Cells and Systems, 2019 Apr 11;23(3):164-169. (First author)

12.  Jeon P, Park JH, Jun YW, Lee YK, Jang DJ, Lee JA. "Development of GABARAP family protein-sensitive LIR-based probes for neuronal autophagy." Molecular Brain, 2019 Apr 8;12(1):33. (Co-author)

13.  Jun YW, Lee JA, Jang DJ. "Phenylarsine oxide and adenosine-sensitive trans-Golgi complex targeting of GFP fused to modified sulfatide-binding peptide." Journal of Life Science, 2018 Feb 28(2):162-169. (First author) (ISSN: 1225-9918)

14.  Jun YW, Lee JA, Jang DJ. "PI4KII activity-dependent Golgi complex targeting of Aplysia phosphodiesterase 4 long-form mutant." Animal Cells and Systems. 2017 Sep 06;21(5):316-322. (First author)

15.  Jang DJ*, Jun YW*, Shim J, Sim SE, Lee JA, Lim CS, Kaang BK. "Activation of Aplysia ARF6 induces neurite outgrowth and is sequestered by the overexpression of the PH domain of Aplysia Sec7 proteins." Neurobiology of Learning and Memory. 2017 Feb 28;138:31-38. (*Co-first author)

16.  Lee YK*, Jun YW*, Choi HE, Huh YH, Kaang BK, Jang DJ, Lee JA. "Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy." EMBO Journal. 2017 Apr 13;36(8):1100-1116. (*Co-first author)

17.  Jun MH, Ryu HH, Jun YW, Liu T, Li Y, Lim CS, Lee YS, Kaang BK, Jang DJ, Lee JA. "Sequestration of PRMT1 and Nd1-L mRNA into ALS-linked FUS mutant R521C-positive aggregates contributes to neurite degeneration upon oxidative stress." Scientific Reports. 2017 Jan 17;7:40474 (Co-author)

18.  Jun YW, Lee YK, Lee JA, Kaang BK, Jang DJ. "Distinct regulations of ARF1 by two Aplysia Sec7 isoforms." Animal Cells and Systems. 2017 Jan 15;21(1):10-16. (First author)

19.  Jun YW, Lee SH, Shim J, Lee JA, Lim CS, Kaang BK, Jang DJ. "Dual roles of the N-terminal coiled-coil domain of an Aplysia sec7 protein: homodimer formation and nuclear export." Neurobiology of Learning and Memory. 2016 Dec 20;139(6):1102-1112. (First author)

20.  Lee SH, Shim J, Cheong YH, Choi SL, Jun YW, Lee SH1, Chae YS, Han JH, Lee YS, Lee JA, Lim CS, Si K, Kassabov S, Antonov I, Kandel ER, Kaang BK, Jang DJ. "ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation." Molecular Brain. 2016 Oct 22;9(1):91. (Co-author)

21.  Jun YW, Lee JA, Jang DJ. "Analysis of the effects of overexpression of specific phospholipid binding proteins on cellular morphological changes in HEK293T cells." Journal of Life Science. 2016 Aug 30;26(8):875-880. (First author) (ISSN: 1225-9918)

22.  Jun YW*, Park H*, Lee YK, Kaang BK, Lee JA, Jang DJ. "D-AKAP1a is a signal-anchored protein in the mitochondrial outer membrane." FEBS Letters. 2016 Apr 13;590(7):954-61. (*Co-first author)

23.  Um SM*, Jun YW*, Kim KH, Lee JA, Jang DJ. "Analysis of molecular mechanism of cellular localization of various N-terminal mutants of Aplysia PDE4 in HEK293T cells." Analytical Science & Technology. 2016 Feb 01;29(1):10-18. (*Co-first author)

24.  Jun YW*, Han DG*, Lee JA, Jo SY, Jang DJ. "Inhibition of proliferation of human fibroblast by δ-aminolevulinic acid (ALA) derivatives through the induction of mitochondria membrane depolarization." The Korean Society for Biotechnology and Bioengineering. 2015 Dec 11;30(6):313-318. (*Co-first author) (ISSN: 1225-7117)

25.  Jun YW, Kim S, Kim KH, Lee JA, Lim CS, Chang I, Suh BC, Kaang BK, Jang DJ. "Analysis of phosphoinositide-binding properties and subcellular localization of GFP-fusion proteins." Lipids. 2015 Apr;50(4):427-36. (First author)

26.  Jun YW, Lee JA, Jang DJ. "Development of intracellular organelle markers using modified glycolipid-binding peptides in mammalian cells." Analytical Science & Technology. 2015 Feb;28(1):65-71. (First author) (ISSN: 1225-0163)

27.  Kim KH*, Jun YW*, Park Y, Lee JA, Suh BC, Lim CS, Lee YS, Kaang BK, Jang DJ. "Intracellular membrane association of the Aplysia cAMP phosphodiesterase long and short forms via different targeting mechanisms." Journal of Biological Chemistry. 2014 Sep 12;289(37):25797-811. (*Co-first author)

28.  Jun YW*, Kim KH*, Lee JA, Jang DJ. "Analysis of the effects of δ-Aminolevulinic acid on the proliferation and apoptosis of mammalian cells." Analytical Science & Technology. 2014 Oct;27(5):223-227. (*Co-first author) (ISSN: 1225-0163)

29.  Jun MH*, Jun YW*, Kim KH, Lee JA, Jang DJ. "Characterization of the cellular localization of C4orf34 as a novel endoplasmic reticulum resident protein." BMB Reports. 2014 Oct 31;47(10):563-8. (*Co-first author)

30.  Kim KH*, Jun YW*, Jo SY, Lee JA, Jang DJ. "Identification of N-terminal amino acids of ApPDE4 involved in targeting to plasma membrane and cellular morphological change by expression of N-terminal peptide." Analytical Science & Technology. 2013 Feb;26(1):106-112. (*Co-first author) (ISSN: 1225-0163)

 

1.  Korean-American Society for Biochemistry and Molecular Biology (KASBP) Fellowship Award in 2021 KASBP Fall eSymposium (2021.11.13)

2.  Postdoctoral Fellowships Certificate, Korea (2019.09.01 – 2020.08.31)

3.  Global Ph.D. Fellowship Certificate, Korea (2016.03.01 – 2019.02.28)

 

1.  Travel Awards in Gordon Research Conference, Frontotemporal Dementia and Related Rare Dementias Conference (2026.02.16)

2.  Excellence in Presentation Award – Neuroscience in KBS in UMass Chan Medical School (2025.12.06)

3.  Outstanding Research Award in 2025 NEBS Annual Conference (2025.05.17)

4.  Outstanding Research Award in 2023 NEBS Annual Conference (2023.05.13)

5.  Best Poster Award in 2022 New England Bioscience Society (NEBS) Annual Conference (2022.05.21)

6.  Young Investigator Awards in 2018 Autophagy Symposium (2018.08.30~31)

7.  Prize winner of Strengthening program of global ability (2018.05.21)
(Incentive Program in Global Ph.D. Fellowship)

8.  Best Poster Award in 2017 Autophagy Symposium (2017.08.24)

9.  Prize winner of Strengthening program of global ability (2017.11.13)
(Incentive Program in Global Ph.D. Fellowship)

10.  Best Poster Award in KSBMB International Conference (2016.05.18)