2007 - 2011             Ph.D. Department of Biological Sciences, Sungkyunkwan University

 

2004 - 2006             M.S. Department of Microbiology, Kyungpook National University

 

1997 - 2004             B.S. Department of Microbiology, Kyungpook National University

2020. 09 - present                    Assistant Professor

Department of Cell Biology,

Daegu Catholic University School of Medicine, Korea

 

2011. 10 – 2020. 08                 Postdoctoral research scientist

Department of Biochemistry and Molecular Biology,  

Korea University College of Medicine, Korea

 

 

 1.      Son SW, Cho E, Cho H, Woo SR, Lee HJ, Oh SJ, Kin S, Kim JH, Chung EJ, Chung JY, Kim MG, Song KH*, Kim TW*. NANOG confers resistance to complement-dependent cytotoxicity in immune-edited tumor cells through up-regulating CD59. Sci Rep. 2022 May 23;12(1):8652. (2021 IF: 4.996) (* co- corresponding authors)

 

2.      Kim S, Heo R, Song SH, Song KH, Shin JM, Oh SJ, Lee HJ, Chung JE, Park JH, Kim TW. PD-L1 siRNA-hyaluronic acid conjugate for dual-targeted cancer immunotherapy. J Control Release. 2022 Jun;346:226-239. (2021 IF: 11.467)

 

3.      Lee HJ, Song KH, Oh SJ, Kim S, Cho E, Kim J, Park YG, Lee KM, Yee C, Song SH, Chang S, Choi J, Jung ST, Kim TW. Targeting TCTP sensitizes tumor to T cell-mediated therapy by reversing immune-refractory phenotypes. Nat Commun. 2022 Apr 19;13(1):2127. (2021 IF: 17.694)

 

4.      Jeong YJ, Hwang SK, Yu MH, Cho Y, Song KH, Magae J, Jeon EJ, Chang YC. 4-O-methylascochlorin-stimulated HIF-1α expression induces the epithelial mesenchymal transition and cell survival in breast cancer cells. Toxicol In Vitro. 2022 Jun;81:105342. (2021 IF: 3.685)

 

5.      Oh SJ, Lee HJ, Song KH, Kim S, Cho E, Lee J, Bosenberg MW, Kim TW. Targeting NANOG/HDAC1 axis reverses resistance to PD-1 blockade by reinvigorating anti-tumor immunity cycle. J Clin Invest. 2022 Feb 1;e147908. (2020 IF: 14.808)

 

6.      Hwang SK, Jeong YJ, Cho HJ, Park YY, Song KH, Chang YC. Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production. J Ginseng Res. 2022 Jan;46(1):138-146. (2021 IF: 5.86)

 

7.      Oh SJ, Noh KH, Song KH*, Kim TW*. Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression. Int. J. Mol. Sci. 2021 Aug 17; 22(16), 8839 (2020 IF: 5.923) (* co- corresponding authors)

 

8.      Lee BR, Lee HJ, Huh J, Yoon CJ, Oh SJ, Song KH, Jeong S, Kim J, Lee KM, Shin BS, Jeong JH, Kim TW, Lee J. Human Ferritin Platform and Its Optimized Structures to Enhance Anti‐Cancer Immunity. Advanced Therapeutics. 2021 Feb; 4(2) 2000208.

 

9.      Kim S, Cho H, Hong SO, Oh SJ, Lee HJ, Cho E, Woo SR, Song JS, Chung JY, Yoon SM, Jeong YM, Jeon S, Yee C, Lee KM, Hewitt SM, Kim JH, Song KH*, Kim TW*. LC3B upregulation by NANOG promotes immune resistance and a stem-like property through hyperactivation of EGFR signaling in immune-edited tumor cells. Autophagy. 2021 Aug 14;1-20 (2020 IF: 16.016) (* co-corresponding authors)

 

10.   Kwak CH*, Song KH* and Cheorl-Ho Kim. Gram-negative bacterial endotoxin LPS induces NeuGc loss through Ets1-dependent downregulation of intestine specific pcmah transcript in porcine intestinal cells. Int J Mol Sci. 2020 Jul 10;21(14), E4892, (2020 IF: 5.923) (* co-first authors)

 

11.   Lee JO, Byun WS, Kang MJ, Han JA, Moon J, Shin MJ, Lee HJ, Chung JH, Lee JS, Son CG, Song KH, Kim TW, Lee ES, Kim HM, Chung CH, Ngoei KRW, Ling NXY, Oakhill JS, Galic S, Segal LM, Kemp BE, Kim KM, Lim S, Kim HS. The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2. FEBS J. 2020 May;287(10):2087-2104. (2020 IF: 5.542)

 

12.   Oh SJ, Lee J, Kim Y, Song KH, Cho E, Kim M, Jung H, Kim TW. Far Beyond Cancer Immunotherapy: Reversion of Multi-Malignant Phenotypes of Immunotherapeutic-Resistant Cancer by Targeting the NANOG Signaling Axis. Immune Netw. 2020 Jan 20;20(1):e7. (2020 IF: 6.303)

 

13.   Song KH*, Oh SJ*, Kim S*, Cho H, Lee HJ, Song JS, Chung JY, Cho E, Lee J, Jeon S, Yee C, Lee KM, Hewitt SM, Kim JH, Woo SR, Kim TW. HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors. Nature communications. 2020 Jan 28;11:562. (2020 IF: 14.919) (* co-first authors)

 

14.   Song KH*, Kwak CH*, Chung TW*, Ha SH, Park JY, Ha KT, Cho SH, Lee YC, Kim CH. Intestine specific regulation of pig cytidine-5'-monophospho-N-acetylneuraminic acid hydroxylase gene for N-glycolylneuraminic acid biosynthesis. Scientific Reports 2019 Mar 12;9(1):4292. (2017 IF: 4.122) (* co-first authors)

 

15.   Woo SR, Lee HJ, Oh SJ, Kim S, Park SH, Lee J, Song KH*, Kim TW*. Stabilization of HDAC1 via TCL1-pAKT-CHFR axis is a key element for NANOG-mediated multi-resistance and stem-like phenotype in immune-edited tumor cells. Biochem Biophys Res Commun. 2018 Sep 10;503(3):1812-1818. (2017 IF: 2.559) (* co-corresponding authors)

 

16.   Song KH*, Kim JH*, Lee YH*, Bae HC*, Lee HJ, Woo SR, Oh SJ, Lee KM, Yee C, Kim BW, Cho H, Chung EJ, Chung JY, Hewitt SM, Chung TW, Ha KT, Bae YK, Mao CP, Yang A, Wu TC, Kim TW. Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance. J Clin Invest. 2018 Aug 31;128(9):4098-4114. (2017 IF: 13.251) (* co-first authors)

 

17.   Oh SJ, Cho H, Kim S, Noh K, Song KH, Lee HJ, Woo SR, Kim S, Choi CH, Chung JY, Hewitt SM, Kim JH, Baek S, Lee KM, Yee C, Park HC, and Kim TW. Targeting Cyclin D-CDK4/6 sensitizes immune-refractory cancer by blocking the SCP3-NANOG axis. Cancer Res. 2018 May 15;78(10):2638-2653 (2017 IF: 9.13)

 

18.   Shin JM, Oh SJ, Kwon S, Deepagan VG, Lee M, Song SH, Lee HJ, Kim S, Song KH, Kim TW, Park JH. A PEGylated hyaluronic acid conjugate for targeted cancer immunotherapy. J Control Release. 2017 Dec 10;267:181-190. (2017 IF: 7.877)

 

19.   Song KH*, Choi CH*, Lee HJ, Oh SJ, Woo SR, Hong SO, Noh KH, Cho H, Chung EJ, Kim JH, Chung JY, Hewitt SM, Baek S, Lee KM, Yee C, Son M, Mao CP, Wu TC, Kim TW. HDAC1 upregulation by NANOG promotes multidrug resistance and a stem-like phenotype in immune edited tumor cells. Cancer Res. 2017 Sep 15;77(18):5039-5053. (2017 IF: 9.13) (* co-first authors)

 

 

20.   Jang HS*, Woo SR*, Song KH*, Cho H, Chay DB, Hong SO, Lee HJ, Oh SJ, Chung JY, Kim JH, Kim TW. API5 induces cisplatin resistance through FGFR signaling in human cancer cells. Exp Mol Med. 8;49(9):e374, 2017 (2017 IF: 5.584) (* co-first authors)

 

21.   Song KH*, Cho H*, Kim S*, Lee HJ, Oh SJ, Woo SR, Hong SO, Jang HS, Noh KH, Choi CH, Chung JY, Hewitt SM, Kim JH, Son M, Kim SH, Lee BI, Park HC, Bae YK, Kim TW. API5 confers cancer stem cell-like properties through the FGF2-NANOG axis. Oncogenesis. 6(1):e285, 2017 (2017 IF: 4.722)

 

22.   Song KH*, Woo SR*, Chung JY, Lee HJ, Oh SJ, Hong SO, Shim J, Kim YN, Rho SB, Hong SM, Cho H, Hibi M, Bae DJ, Kim SY, Kim MG, Kim TW, Bae YK. REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. Cell Death Dis. 8(1):e2536, 2017 (2017 IF: 5.638)

 

23.   Lee H, Ryu WI, Kim HJ, Bae HC, Ryu HJ, Shin JJ, Song KH, Kim TW, Son SW. TSLP Down-Regulates S100A7 and ß-Defensin 2 Via the JAK2/STAT3-Dependent Mechanism. J Invest Dermatol. 136(12):2427-2435, 2016 (2017 IF: 6.448)

 

24.   Song KH*, Kwak CH*, Jin UH, Ha SH, Park JY, Abekura F, Chang YC, Cho SH, Lee K, Chung TW, Ha KT, Lee YC, Kim CH. Housekeeping promoter 5'pcmah-2 of pig CMP-N-acetylneuraminic acid hydroxylase gene for NeuGc expression. Glycoconj J. 33(5):779-88, 2016 (2017 IF: 2.548) (* co-first authors)

 

25.   Oh SJ, Noh KH, Lee YH, Hong SO, Song KH, Lee HJ, Kim S, Kim TM, Jeon JH, Seo JH, Kim DW, Kim TW. Targeting stemness is an effective strategy to control EML4-ALK+ non-small cell lung cancer cells. Oncotarget. 6(37):40255-67, 2015  (2016 IF: 5.168)

 

26.   Ahn YH, Hong SO, Kim JH, Noh KH, Song KH, Lee YH, Jeon JH, Kim DW, Seo JH, Kim TW. The siRNA cocktail targeting IL-10 receptor and TGF-β receptor on dendritic cells potentiates tumor antigen-specific CD8(+) T cell immunity. Clin Exp Immunol. 181(1):164-78, 2015 (2017 IF: 3.542)

 

27.   Song KH*, Kim SH*, Noh KH*, Bae HC, Kim JH, Lee HJ, Song J, Kang TH, Kim DW, Oh SJ, Jeon JH, Kim TW. Apoptosis Inhibitor 5 Increases Metastasis via Erk-mediated MMP expression. BMB Rep. 48(6):330-5, 2015 (2017 IF: 3.085)

 

28.   Lee HJ, Noh KH, Lee YH, Song KH, Oh SJ, Kim SY, Kim TW. NANOG signaling promotes metastatic capability of immunoedited tumor cells. Clin Exp Metastasis. 32(5):429-39, 2015 (2017 IF: 3.455)

 

29.   Lee YH, Bae HC, Noh KH, Song KH, Ye SK, Mao CP, Lee KM, Wu TC, Kim TW. Gain of HIF-1α under normoxia in cancer mediates immune adaptation through the AKT/ERK and VEGFA axes. Clin Cancer Res. 21(6):1438-46, 2015 (2017 IF: 10.199)

 

30.   Lee YH, Yoon HY, Shin JM, Saravanakumar G, Noh KH, Song KH, Jeon JH, Kim DW, Lee KM, Kim K, Kwon IC, Park JH, Kim TW. A polymeric conjugate foreignizing tumor cells for targeted immunotherapy in vivo. J Control Release. 199:98-105, 2015 (2017 IF: 7.877)

 

31.   Mao CP, Wu TC, Song KH, Kim TW. Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion. OncoImmunology. 3(7):e947871, 2014 (2017 IF: 6.283)

 

32.   Noh KH, Park YM, Kim HS, Kang TH, Song KH, Lee YH, Byeon Y, Jeon HN, Jung ID, Shin BC, Lee KM, Seong SY, Han HD, Kim TW. GM-CSF-loaded chitosan hydrogel as an immunoadjuvant enhances antigen-specific immune responses with reduced toxicity. BMC Immunol. 15:48, 2014 (2017 IF: 2.615)

 

33.   Chung TW, Kim SJ, Choi HJ, Song KH, Jin UH, Yu DY, Seong JK, Kim JG, Kim KJ, Ko JH, Ha KT, Lee YC, Kim CH. Hepatitis B virus X protein specially regulates the sialyl lewis a synthesis among glycosylation events for metastasis. Mol Cancer. 13:222, 2014 (2017 IF: 7.776)

 

34.   Cho H, Chung JY, Song KH, Noh KH, Kim BW, Chung EJ, Ylaya K, Kim JH, Kim TW, Hewitt SM, Kim JH. Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer. BMC Cancer. 14:545, 2014 (2017 IF: 3.288)

 

35.   Jin UH, Chung TW, Song KH, Kwak CH, Choi HJ, Ha KT, Chang YC, Lee YC, Kim CH. Ganglioside GM3 is required for caffeic acid phenethyl ester-induced megakaryocytic differentiation of human chronic myelogenous leukemia K562 cells. Biochem Cell Biol. 92(4):243-9, 2014 (2017 IF: 2.25)

 

36.   Chung TW, Choi HJ, Kim SJ, Kwak CH, Song KH, Jin UH, Chang YC, Chang HW, Lee YC, Ha KT, Kim CH. The ganglioside GM3 is associated with cisplatin-induced apoptosis in human colon cancer cells. PLoS One. 9(5):e92786, 2014 (2017 IF: 2.766)

 

37.   Noh KH, Kim SH, Kim JH, Song KH, Lee YH, Kang TH, Han HD, Sood AK, Ng J, Kim K, Sonn CH, Kumar V, Yee C, Lee KM, Kim TW. API5 confers tumoral immune escape through FGF2-dependent cell survival pathway. Cancer Res. 74(13):3556-66, 2014 (2017 IF: 9.13)

 

38.   Kim SJ, Chung TW, Choi HJ, Kwak CH, Song KH, Suh SJ, Kwon KM, Chang YC, Park YG, Chang HW, Kim KS, Kim CH, Lee YC. Ganglioside GM3 participates in the TGF-β1-induced epithelial-mesenchymal transition of human lens epithelial cells. Biochem J. 449(1):241-51, 2013 (2013 IF: 4.779)

 

39.   Chung TW, Kim SJ, Choi HJ, Kwak CH, Song KH, Suh SJ, Kim KJ, Ha KT, Park YG, Chang YC, Chang HW, Lee YC, Kim CH. CAPE suppresses VEGFR-2 activation, and tumor neovascularization and growth. J Mol Med (Berl). 449(1):241-51, 2013 (2013 IF: 4.739)

 

40.   Kim KA, Chung SB, Hawng EY, Noh SH, Song KH, Kim HH, Kim CH, Park YG. Correlation of expression and activity of matrix metalloproteinase-9 and -2 in human gingival cells of periodontitis patients. J Periodontal Implant Sci. 43(1):24-9, 2013 (2014 IF: 1.145)

 

41.   Noh KH*, Kim BW*, Song KH*, Cho H*, Lee YH, Kim JH, Chung JY, Kim JH, Hewitt SM, Seong SY, Mao CP, Wu TC, Kim TW. Nanog signaling in cancer promotes stem-like phenotype and immune evasion. J Clin Invest. 122(11):4077-93, 2012 (2013 IF: 13.765) (* co-first authors)

 

42.   Suh SJ, Kwak CH, Song KH, Kwon KM, Chung TW, Cho SH, Kim YK, Yoon HD, Lee YC, Kim DS, Park SJ, Na MK, Son JK, Chang HW, Kim CH. Triple inhibitory activity of Cliona celata against TNF-α-induced matrix metalloproteinase-9 production via downregulated NF-κB and AP-1, enzyme activity, and migration potential. Inflammation. 35(2):736-45, 2012 (2013 IF: 1.921)

 

43.   Son SW, Song KH, Kwon HY, Kim KS, Kim CH, Oh KB, Choo YK, Lee YC. Transcriptional activation of pig Galβ1,3GalNAc α2,3-sialyltransferase (pST3Gal I) gene by TGF-β1 in porcine kidney PK-15 cells. Biochem Biophys Res Commun. 414(1):159-64, 2011 (2013 IF: 2.281)

 

44.   Suh SJ, Ko HK, Song KH, Kim JR, Kwon KM, Chang YC, Lee YC, Kim DS, Park SJ, Yang JH, Son JK, Na MK, Chang HW, Kim CH. Ethylacetate fraction from Korean seaside starfish, Asterias amurensis, has an inhibitory effect on MMP-9 activity and expression and on migration behavior of TNF-α induced human aortic smooth muscle cells. Toxicol In Vitro. 25(4):767-73, 2011 (2013 IF: 3.207)

 

45.   Ko HK, Song KH, Jin UH, Seong HH, Chang YC, Kim NH, Kim DS, Lee YC, Kim CH. Molecular characterization of pig alpha2,3-Gal-beta1,3-GalNAc-alpha2,6-sialyltransferase (pST6GalNAc IV) gene specific for Neu5Acalpha2-3Galbeta1-3GalNAc trisaccharide structure. Glycoconj J. 27(3):367-74, 2010 (2013 IF: 1.948)

 

46.   Song KH, Kang YJ, Jin UH, Park YI, Kim SM, Seong HH, Hwang S, Yang BS, Im GS, Min KS, Kim JH, Chang YC, Kim NH, Lee YC, Kim CH. Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-human xenotransplantation. Biochem J. 427(1):179-88, 2010 (2013 IF: 4.779)

 

47.   Kang SK, Kim YS, Kong YJ, Song KH, Chang YC, Park YG, Ko JH, Lee YC, Kim CH. Disialoganglioside GD3 synthase expression recruits membrane transglutaminase 2 during erythroid differentiation of the human chronic myelogenous leukemia K562 cells. Proteomics. 8(16):3317-28, 2008 (2013 IF: 3.973)

 

48.   Jin UH*, Song KH*, Motomura M, Suzuki I, Gu YH, Kang YJ, Moon TC, Kim CH. Caffeic acid phenethyl ester induces mitochondria-mediated apoptosis in human myeloid leukemia U937 cells. Mol Cell Biochem. 310(1-2):43-8, 2008 (2013 IF : 2.388) (* co-first authors)