신은경 교수 (Eunkyoung Shin)
2006.02 중앙대학교 생명과학과 이학사 졸업
2007.08 중앙대학교 생명과학과 이학석사 졸업
2010.08 중앙대학교 생명과학과 이학박사 졸업
2010 - 2013 중앙대학교 생명과학과 미생물학연구실 Post-Doc.
2013 - 2018 중앙대학교 약학대학 예방약학연구실 Post-Doc.
2018 - 2023 중앙대학교 생명과학과 연구교수
2024 - 현재 대구가톨릭대학교 의과대학 의예과 조교수
1. Yeom J-H*, Shin E*, Jin H*, Liu H, Luo Y, Nam Y, Ryu M, Song W, Chi H, Kim J, Lee K and Bae J. Aptamer-conjugated gold nanoparticles platform as the intracellular delivery of antibodies for cancer therapy. J Ind Eng Chem. (2023) Oct 25; 126: 480-491. *co-first author
2. Choi Y*, Shin E*, Lee M, Yeom J-H, and Lee K. Functional
conservation of specialized ribosomes bearing genome-encoded variant rRNAs in
Vibrio species. PLoS ONE (2023) Dec 5; 18(12): e0289072. *co-first author
3. Bae D, Hyeon H, Shin E, Yeom J-H, and Lee K. Relaxed
Cleavage Specificity of Hyperactive Variants of Escherichia coli RNase E on RNA
I. J Microbiol. (2023) Feb 1; 61(2): 2211-220. doi: 10.1007/s12275-023-00013-z.
4. Choi Y*, Joo M*, Song W*, Lee M, Jun H, Hyeon H, Kim H-L,
Yeom J-H, Lee K†, and Shin E†. Transcript-specific selective translation by
specialized ribosomes bearing genome-encoded heterogeneous rRNAs in V.
vulnificus CMCP6. J Microbiol. (2022) Dec 1; 60(12): 1162-1167. doi:
10.1007/s12275-022-2437-9. †co-corresponding
5. Joo M*, Yeom J-H*, Choi Y, Jun H, Song W, Kim H-L, Lee K†,
and Shin E†. Specialised ribosomes as versatile regulators of gene expression.
RNA Biology. (2022) Oct 18; 19(1):1103-1114. doi:10.1080/15476286.2022.2135299. †co-corresponding (Review)
6. Lee J*, Shin E*, Yeom J-H, Park J, Kim SW, Lee M, and Lee
K. Regulator of RNase E activity modulates the pathogenicity of Salmonella
Typhimurium. Microb Pathog. (2022) Feb 26;165:105460. doi:10.1016/j.micpath.2022.105460. *co-first author
7. Park J*, Shin E*, Yeom J-H, Choi Y, Joo M, Lee M, Kim JH,
Bae J, and Lee K. Gold nanoparticle-DNA aptamer-assisted delivery of
antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in
mice. J Microbiol. (2022) Jan; 60(1): 128-136 *co-first author
8. Lee J*, Shin E*, Park J, Lee M, and Lee K. Regulator of
ribonuclease activity modulates the pathogenicity of Vibrio vulnificus. J
Microbiol. (2021) Dec;59(12):1133-1141 *co-first author
9. Lee M, Ryu M, Joo M, Seo Y-J, Lee J, Kim H-M, Shin E, Yeom
J-H, Kim Y-H, Bae J, and Lee K. Endoribonuclease-mediated control of hns mRNA
stability constitutes a key regulatory pathway for Salmonella Typhimurium
pathogenicity island 1 expression. PLoS Pathog. (2021) Feb 1; 17(2): e1009263.
doi.org/10.1371/journal ppat.1009263
10. Moore C. J*, Go H*, Shin E*, Ha H-J, Song S, Ha N-C, Kim
Y-H, Cohen S. N. Lee K. Substrate-dependent effects of quaternary structure on
RNase E activity. Genes Dev. (2021) Jan 14; 35:286–299 doi:
10.1101/gad.335828.119 *co-first author
11. Shin E*, Jin H*, Suh DS*, Luo Y, Ha HJ, Kim TH, Hahn Y, Hyun
S, Lee K, Bae J. An alternative miRISC targets a cancer‐associated
coding sequence mutation in FOXL2. EMBO J. (2020) Dec 15; 39(24): e104719.
*co-first author
12. Song W*, Joo M*, Yeom JH*, Shin E*, Lee M*, Choi HK, Hwang
J, Kim YI, Seo R, Lee JE, Moore CJ, Kim YH, Eyun SI, Hahn Y, Bae J, Lee K.
Divergent rRNAs as regulators of gene expression at the ribosome level. Nat
Microbiol. (2019) Mar;4(3):515-526. *co-first author
13. Won M, Luo Y, Lee DH, Shin E, Suh DS, Kim TH, Jin H, Bae J.
BAX is an essential key mediator of AP5M1-induced apoptosis in cervical
carcinoma cells. Biochem Biophys Res Commun. (2019) Oct 15;518(2):368-373
14. Jin H, Won M, Shin E, Kim HM, Lee K, Bae J. EGR2 is a
gonadotropin-induced survival factor that controls the expression of IER3 in
ovarian granulosa cells. Biochem Biophys Res Commun. (2017) Jan
22;482(4):877-882.
15. Lim B, Sim M, Lee H, Hyun S, Lee Y, Hahn Y, Shin E †, Lee
K†. Regulation of Escherichia coli RNase III activity. J Microbiol. (2015)
Aug;53(8):487-94. †co-corresponding (Review)
16. Suh DS, Oh HK, Kim JH, Park S, Shin E, Lee K, Kim YH, Bae J.
Identification and Validation of Differential Phosphorylation Sites of the
Nuclear FOXL2 Protein as Potential Novel Biomarkers for Adult-Type Granulosa
Cell Tumors. J Proteome Res. (2015) Jun 5;14(6):2446-56.
17. Kim D, Song S, Lee M, Go H, Shin E, Yeom JH, Ha NC, Lee K,
Kim YH. Modulation of RNase E activity by alternative RNA binding sites. PLoS
One. (2014) Mar 5;9(3):e90610.
18. Park M*, Shin E*, Won M, Kim JH, Go H, Kim HL, Ko JJ, Lee K,
Bae J. FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses
SF-1-induced CYP17 transcription in granulosa cells. Mol Endocrinol. (2010) May
24(5):1024-36. *co-first author
19. Sim SH, Yeom JH, Shin C, Song WS, Shin E, Kim HM, Cha CJ,
Han SH, Ha NC, Kim SW, Hahn Y, Bae J, Lee K. Escherichia coli ribonuclease III
activity is downregulated by osmotic stress: consequences for the degradation
of bdm mRNA in biofilm formation. Mol Microbiol. (2010) Jan 75(2):413-25.
20. Yeom JH, Go H, Shin E, Kim HL, Han SH, Moore CJ, Bae J, Lee
K. Inhibitory effects of RraA and RraB on RNAse E-related enzymes imply
conserved functions in the regulated enzymatic cleavage of RNA. FEMS Microbiol
Lett. (2008) Aug 285(1), 10-15.
21. Shin E*, Go H*, Yeom JH, Won M, Bae J, Han SH, Han K, Lee Y,
Ha NC, Moore CJ, Sohlberg B, Cohen SN, Lee K. Identification of amino acid
residues in the catalytic domain of RNase E essential for survival of
Escherichia coli: functional analysis of DNase I subdomain. Genetics (2008) Aug
179(4), 1871-1879. *co-first author
22. Kim HL, Shin E, Kim HM, Go H, Roh J, Bae J, Lee K.
Heterogeneous rRNA molecules encoded by Streptomyces coelicolor M145 genome are
all expressed and assembled into ribosomes. J Microbiol Biotechnol. (2007) Oct
17(10), 1708-1711.
23. Kim HL, Shin EK, Kim HM, Ryou SM, Kim S, Cha CJ, Bae J, Lee
K. Heterogeneous rRNAs are differentially expressed during the morphological
development of Streptomyces coelicolor. FEMS Microbiol Lett. (2007) Oct 275(1),
146-152